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KMID : 0900919970210010061
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Korean journal of Animal Reproduction
1997 Volume.21 No. 1 p.61 ~ p.69
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Effect of Epidermal Growth Factor (EGF) and anti-EGF on Early Embryonic Development in Mice
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Abstract
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The present study was carried out to investigate the effects of EGF and anti-EGF on early embryonic development and hatching in mice. Developmental and hatching rates of mouse em-bryos from 2-cell to morular stage which were cultured in Ham’s FlO medium supplemented with EGF (1-1,000 ng/ml) or anti-EGF (whole serum diluted from 1:10 to 1:1,000) were compared to those of control When mouse early 2-cell embryos were cultured in the EGF supplemented medium, blastulation was accelerated compared with control. Hatching rate was also significantly (p
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KEYWORD
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EGF, Anti-EGF, Blocking, Blastulation, Hatching
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